News & Updates

How Can Polynucleotides Help To Treat Perimenopausal Skin?

8 September 2026
by Grand Aesthetics

Menopause and perimenopause affect every system in the body, including the skin, but thanks to treatments such as polynucleotides, these effects can often be managed or treated.

The latter can cause fluctuations in your hormones, which can have a significant and noticeable effect on your skin, the body’s largest organ.

Taking care of your skin before, during and following the menopause, therefore, requires a long-term approach that focuses on repairing and rebuilding the building blocks of your skin from within.

Could polynucleotides be the treatment for you? To find out, it is important to understand how and why perimenopause and menopause affect your skin, what polynucleotides can do to help it, and why it helps to treat the causes rather than the surface details.

 

Why Does Menopause And Perimenopause Affect The Skin So Much?

Menopause is the end of the reproductive cycle, which has effects throughout the body, but the biggest change that affects the skin is a lower natural production of oestrogen.

Oestrogen regulates many of the functions that help keep skin glowing, smooth and plump, including:

  • The production of collagen
  • The retaining of moisture and oil in the skin
  • Elasticity in the skin
  • Blood flow around the skin
  • Skin barrier protection and the mending of cuts and scarring

All of this causes postmenopausal skin to typically be thinner, more flaky due to dehydration, have more visible fine lines, be more sensitive, have less of a glowing complexion and lead to skin conditions such as acne and hyperpigmentation.

 

How Can Polynucleotides Help With Menopausal Skin?

A DNA-derived injectable treatment, polynucleotides can help with many of the skin changes caused by perimenopause and menopause because they are not focused on treating individual symptoms at the surface level but help to boost your skin from the inside.

This not only helps improve the appearance of your skin but can provide lasting benefits that ensure you maintain healthy skin for years afterwards, as they are a very natural approach that provides a subtle glow rather than a substantial transformation.

Here are just some of the ways in which polynucleotides can help you and the types of menopause-derived skin conditions it can help to treat.

It Innately Regenerates The Skin

Polynucleotides primarily work by stimulating fibroblast cells, which themselves help to build up the vital elastin and collagen tissues necessary for healthy skin.

Beyond this, they also help to boost hydration by strengthening the extracellular matrix of your skin cells, help relieve inflammation within the skin and more effectively manage pigmentation.

They work from the DNA outwards, regenerating your skin from within and encouraging the production of everything the skin needs, rather than adding it externally.

It Is Naturally Hydrating

Rather than filling targeted areas with a gel that helps to boost skin volume, polynucleotides strengthen the water-retaining structure of the skin, helping to boost hydration and provide a natural glow.

It Can Soften Wrinkles In Hard To Treat Areas

Polynucleotides are particularly effective at helping treat skin around the neck, jaw, mouth and under the eyes, all of which are naturally thinner than the rest and require more complex filler treatments otherwise.

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